2-Thiazolamine, 4-(trifluoromethyl)- → Benzamide, 2,6-dichloro-N-(((4-(trifluoromethyl)-2-thiazolyl)amino)carbonyl)-
Reaction equation
[F:1][C:2]([F:10])([F:9])[C:3]1[N:4]=[C:5]([NH2:8])[S:6][CH:7]=1.[Cl:11][C:12]1[CH:22]=[CH:21][CH:20]=[C:19]([Cl:23])[C:13]=1[C:14]([N:16]=[C:17]=[O:18])=[O:15]>C(OC(=O)C)C>[Cl:11][C:12]1[CH:22]=[CH:21][CH:20]=[C:19]([Cl:23])[C:13]=1[C:14]([NH:16][C:17]([NH:8][C:5]1[S:6][CH:7]=[C:3]([C:2]([F:10])([F:9])[F:1])[N:4]=1)=[O:18])=[O:15]Participants
4
Procedure
To a solution of 1.7 g (0.01 mole) of 4-trifluoromethyl-2-aminothiazole in 50 ml of dry ethylacetate was added all at once to a solution of 2.16 g (0.01 mole) of freshly prepared 2,6-dichlorobenzoylisocyanate dissolved in 10 ml of dry ethylacetate. The mixture was allowed to stir at 25° for 4 hours. The solvent was evaporated in vacuo, ether was added to the residue, and the solid was removed by filtration to give 3.7 g of product, m.p. 210°-213°. The infrared and nuclear magnetic resonance spectra were consistent with the proposed structure.