Water → HCID 178511480, compound

HRID 26158

Reaction equation

HRID 26158 reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]([S:8]([CH2:11][C:12]#[N:13])(=O)=[O:9])=[CH:4][CH:3]=1.[ClH:14].[NH2:15][OH:16].[OH2:17].C([O-])([O-])=O.[Na+].[Na+]>C(O)C>[Cl:14][C:2]1[CH:3]=[CH:4][C:5]([S:8]([CH2:11][C:12](=[NH:13])[NH:15][OH:16])(=[O:9])=[O:17])=[CH:6][CH:7]=1

Participants

6

Reactant 4

HCID 962Water2×HCID 10340Sodium CarbonateHCID 443297Hydroxyamine hydrochlorideHCID 7358292-(4-Chlorobenzenesulfonyl)acetonitrile

Product 1

HCID 178511480HCID 178511480, compoundYield 70%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

50 g. (0.23 mole) of 4-chlorophenylsulfonylacetonitrile were dissolved in 1.5 liters of ethanol and 16 g. (0.23 mole) of hydroxylamine HCl in 150 ml. of water was added to this solution, followed by the addition of 14.4 g. (0.12 mole) of Na2CO3 in 150 ml. of water. This reaction mixture was stirred at room temperature overnight. 58 g. crude product were filtered off; this was recrystallized from about 2.5 liters of ethanol to give 40 g. of the product (70% yield).

Workup

  1. additionfollowed by the addition of 14.4 g
  2. filtrationcrude product were filtered off
  3. customthis was recrystallized from about 2.5 liters of ethanol
  4. customto give 40 g

Sources & evidence

ORD record
ord-cfb04106ce044c1b82b83425a88a2633
Source dataset
uspto-grants-1979_04
Patent number
US04148801

Linked notes

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