Diglyme → HCID 13101068, compound
Reaction equation
Cl[C:2]1[S:3][N:4]=[C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=12.Cl.Cl.[CH2:13]([N:15]([CH2:18][C:19]1[CH:20]=[C:21]([CH:23]=[CH:24][C:25]=1[OH:26])[NH2:22])[CH2:16][CH3:17])[CH3:14].COCCOCCOC>O>[CH2:13]([N:15]([CH2:18][C:19]1[CH:20]=[C:21]([NH:22][C:2]2[S:3][N:4]=[C:5]3[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=23)[CH:23]=[CH:24][C:25]=1[OH:26])[CH2:16][CH3:17])[CH3:14]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
Following a procedure similar to that described in Example 14 but reacting 10 g. of 3-chloro-2,1-benzisothiazole with 21 g. of 3-(diethylamino)methyl-4-hydroxyaniline dihydrochloride in 30 ml. of diglyme and 20 ml. of water there was obtained 3-{[3-(diethylamino)methyl-4-hydroxyphenyl]amino}-2,1-benzisothiazole, m.p. 164°-165° C.