Cysteamine Hydrochloride → 2-{[(3-Methoxypyridin-2-yl)methyl]sulfanyl}ethan-1-amine
Reaction equation
[Na].Cl.[NH2:3][CH2:4][CH2:5][SH:6].Cl.Cl[CH2:9][C:10]1[C:15]([O:16][CH3:17])=[CH:14][CH:13]=[CH:12][N:11]=1>C(O)C>[NH2:3][CH2:4][CH2:5][S:6][CH2:9][C:10]1[C:15]([O:16][CH3:17])=[CH:14][CH:13]=[CH:12][N:11]=1Participants
5
Procedure
To a solution of sodium (1.65 g) in ethanol (75 ml) was added cysteamine hydrochloride (2.9 g) and after stirring for 5 minutes a solution of 2-chloromethyl-3-methoxypyridine hydrochloride (4.5 g) in ethanol (75 ml) was added over 25 minutes. The mixture was stirred for 2 hours at 15° and the sodium chloride was filtered off and the filtrate was evaporated to give 2-[2-aminoethylthiomethyl]-3-methoxypyridine (4.6 g) as a colourless oil.
Workup
- additionwas added over 25 minutes
- filtrationthe sodium chloride was filtered off
- customthe filtrate was evaporated
Sources & evidence
- ORD record
- ord-0b46dd38eb3640ba94ee808e600d8741
- Source dataset
- uspto-grants-1979_05
- Patent number
- US04154838
Reaction notes
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