Formicin → 3-Acetamidomethylthio-2-methylpropanoic acid

HRID 262582Notes

Reaction equation

HRID 262582 reaction equation
[SH:1][CH2:2][CH:3]([CH3:7])[C:4]([OH:6])=[O:5].O[CH2:9][NH:10][C:11](=[O:13])[CH3:12]>FC(F)(F)C(O)=O>[C:11]([NH:10][CH2:9][S:1][CH2:2][CH:3]([CH3:7])[C:4]([OH:6])=[O:5])(=[O:13])[CH3:12]

Participants

4

Reactant 2

HCID 69365FormicinHCID 1529103-Mercaptoisobutyric acid

Product 1

HCID 213191453-Acetamidomethylthio-2-methylpropanoic acid

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

3-Mercapto-2-methylpropanoic acid (2.4 g.) and N-hydroxymethylacetamide (1.8 g.) are dissolved in trifluoroacetic acid and the solution is stored at room temperature for one hour. The trifluoroacetic acid is removed in vacuo and the residue is dried in vacuo over potassium hydroxide to yield 3-acetamidomethylthio-2-methylpropanoic acid.

Workup

  1. customThe trifluoroacetic acid is removed in vacuo
  2. dry with materialthe residue is dried in vacuo over potassium hydroxide

Sources & evidence

ORD record
ord-0608b8bc62914d75bd49bba4023019fe
Source dataset
uspto-grants-1979_05
Patent number
US04154840

Reaction notes

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