Hydrochloric Acid → 1-(2-Mercaptomethyl-3-mercaptopropanoyl)-L-proline
Reaction equation
C([S:4][CH2:5][CH:6]([CH2:17][S:18]C(=O)C)[C:7]([N:9]1[CH2:16][CH2:15][CH2:14][C@H:10]1[C:11]([OH:13])=[O:12])=[O:8])(=O)C.Cl>O.N>[SH:4][CH2:5][CH:6]([CH2:17][SH:18])[C:7]([N:9]1[CH2:16][CH2:15][CH2:14][C@H:10]1[C:11]([OH:13])=[O:12])=[O:8]Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
1-[(2-Acetylthiomethyl-3-(acetylthio)propanoyl]-L-proline (1.2 g.) is dissolved in a mixture of water (12 ml.) and concentrated ammonia (12 ml.) under an atmosphere of argon. After twenty minutes, the mixture is acidified with concentrated hydrochloric acid. The crystalline precipitate 1-(2-mercaptomethyl-3-mercaptopropanoyl)-L-proline is filtered and dried, yield 0.63 g., m.p. 138°-140°.
Workup
- waitAfter twenty minutes
- filtrationThe crystalline precipitate 1-(2-mercaptomethyl-3-mercaptopropanoyl)-L-proline is filtered
- customdried
Sources & evidence
- ORD record
- ord-9af1b5ea1f4e4e75baae01eb06eae8b1
- Source dataset
- uspto-grants-1979_05
- Patent number
- US04154936
Reaction notes
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