Oxetane → 3-[N'-(3-Hydroxypropyl)-N'-methylamino]-N,N,N-trimethyl-1-propanaminium Bromide

HRID 263167

Reaction equation

HRID 263167 reaction equation
[O:1]1[CH2:4][CH2:3][CH2:2]1.[Br-:5].[CH3:6][N+:7]([CH3:14])([CH3:13])[CH2:8][CH2:9][CH2:10][NH:11][CH3:12]>O>[Br-:5].[OH:1][CH2:2][CH2:3][CH2:4][N:11]([CH2:10][CH2:9][CH2:8][N+:7]([CH3:14])([CH3:13])[CH3:6])[CH3:12]

Participants

4

Reactant 2

HCID 10423OxetaneHCID 21444211N,N,N-Trimethyl-3-(methylamino)propan-1-aminium bromide

Product 1

HCID 233475683-[N'-(3-Hydroxypropyl)-N'-methylamino]-N,N,N-trimethyl-1-propanaminium Bromide

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 20 g. of oxetane (0.34 mole), 32.8 g. of N,N,N-trimethyl-[3-(methylamino)]-1-propanaminium bromide (0.156 mole) and 22 ml. water is heated in a sealed tube at 100° for 15 hours. The solution is evaporated in vacuo and the residue is dissolved in 50 ml. of acetonitrile and filtered. Upon evaporation the desired product crystallizes. The product may be recrystallized from acetonitrile.

Workup

  1. additionA mixture of 20 g
  2. customThe solution is evaporated in vacuo
  3. dissolutionthe residue is dissolved in 50 ml
  4. filtrationof acetonitrile and filtered
  5. customUpon evaporation the desired product
  6. customcrystallizes
  7. customThe product may be recrystallized from acetonitrile

Sources & evidence

ORD record
ord-f2c120316ee347cb8ea232a7c1248f59
Source dataset
uspto-grants-1979_05
Patent number
US04156693

Linked notes

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