Oxetane → 3-[N'-(3-Hydroxypropyl)-N'-methylamino]-N,N,N-trimethyl-1-propanaminium Bromide
Reaction equation
[O:1]1[CH2:4][CH2:3][CH2:2]1.[Br-:5].[CH3:6][N+:7]([CH3:14])([CH3:13])[CH2:8][CH2:9][CH2:10][NH:11][CH3:12]>O>[Br-:5].[OH:1][CH2:2][CH2:3][CH2:4][N:11]([CH2:10][CH2:9][CH2:8][N+:7]([CH3:14])([CH3:13])[CH3:6])[CH3:12]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of 20 g. of oxetane (0.34 mole), 32.8 g. of N,N,N-trimethyl-[3-(methylamino)]-1-propanaminium bromide (0.156 mole) and 22 ml. water is heated in a sealed tube at 100° for 15 hours. The solution is evaporated in vacuo and the residue is dissolved in 50 ml. of acetonitrile and filtered. Upon evaporation the desired product crystallizes. The product may be recrystallized from acetonitrile.
Workup
- additionA mixture of 20 g
- customThe solution is evaporated in vacuo
- dissolutionthe residue is dissolved in 50 ml
- filtrationof acetonitrile and filtered
- customUpon evaporation the desired product
- customcrystallizes
- customThe product may be recrystallized from acetonitrile
Sources & evidence
- ORD record
- ord-f2c120316ee347cb8ea232a7c1248f59
- Source dataset
- uspto-grants-1979_05
- Patent number
- US04156693
Reaction notes
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