Sodium Cyanide → 4-amino-1-methylpiperidine-4-carbonitrile

HRID 264019

Reaction equation

HRID 264019 reaction equation
[OH-].[NH4+:2].[Cl-].[NH4+:4].[C-:5]#N.[Na+].[CH3:8][N:9]1[CH2:14][CH2:13][CH2:12][CH2:11][C:10]1=O>>[NH2:2][C:12]1([C:5]#[N:4])[CH2:13][CH2:14][N:9]([CH3:8])[CH2:10][CH2:11]1

Participants

5

Reactant 4

HCID 8929Sodium CyanideHCID 13603N-Methyl-2-piperidoneHCID 14923Ammonium HydroxideHCID 25517Ammonium Chloride

Product 1

HCID 114349914-amino-1-methylpiperidine-4-carbonitrile

Procedure

Using the procedure of Stage 1 of Example 1, 8 ml of ammonium hydroxide, 1.58 g of ammonium chloride and 1.23 g of sodium cyanide were reacted and 2.5 ml of 1-methylpiperidone were added. The mixture was stirred for 18 hours at ambient temperature, followed by extraction r3 times with chloroform. The organic phase was washed with salt water and dried to obtain 2.41 g of the expected product (orange-yellow syrup).

Workup

  1. customwere reacted
  2. extractionfollowed by extraction r3 times with chloroform
  3. washThe organic phase was washed with salt water
  4. customdried

Sources & evidence

ORD record
ord-dc5971b1cb52476e8660ccef912bd5c0
Source dataset
uspto-grants-1997_07
Patent number
US05646172

Linked notes

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