Hydrochloric Acid → 4-(2-Pyrrolidin-1-yl-ethoxy)-benzoic acid

Reaction equation

[N:1]1([CH2:6][CH2:7][O:8][C:9]2[CH:18]=[CH:17][C:12]([C:13]([O:15]C)=[O:14])=[CH:11][CH:10]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.Cl>>[N:1]1([CH2:6][CH2:7][O:8][C:9]2[CH:10]=[CH:11][C:12]([C:13]([OH:15])=[O:14])=[CH:17][CH:18]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 18617411Methyl 4-(2-Pyrrolidinylethyloxy)benzoate

Product 1

HCID 65042284-(2-Pyrrolidin-1-yl-ethoxy)-benzoic acid

Procedure

Compound 27-6 (1.5 g, 6.0 mmol) was treated with 6N HCl for 48 hours at room temperature and 60° C. for 2 hours. The solvent was removed to give 27-7 as a white solid.

Workup

customThe solvent was removed

Sources & evidence

ORD record: ord-b8adc378d9c94cd4969665ed965d3496
Source dataset: uspto-grants-1997_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05648368

Reaction notes

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