Triethyl 2-phosphonopropionate → 2-Phosphonopropionic acid
Reaction equation
C([O:3][C:4](=[O:15])[CH:5]([P:7]([O:12]CC)([O:9]CC)=[O:8])[CH3:6])C>Cl>[P:7]([CH:5]([CH3:6])[C:4]([OH:15])=[O:3])([OH:12])([OH:9])=[O:8]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of ethyl-2-(diethoxyphosphinyl)propionate (15 g., 0.063 moles) in 6 N hydrochloric acid (150 ml.) is heated to reflux for 2.5 hours. After this time, the reaction vessel is fitted with a Dean-Stark trap and heated at reflux an additional thirty minutes. The reaction mixture is concentrated in vacuo to yield 2-phosphonopropionic acid (quantitative).
Workup
- temperatureis heated
- temperatureto reflux for 2.5 hours
- customAfter this time, the reaction vessel is fitted with a Dean-Stark trap
- temperatureheated
- temperatureat reflux an additional thirty minutes
- concentrationThe reaction mixture is concentrated in vacuo
Sources & evidence
- ORD record
- ord-51634a379c774f2fb0c7ff187d1ea7c9
- Source dataset
- uspto-grants-1979_04
- Patent number
- US04151172
Reaction notes
Loading…