Anisole → N-(4-formyl-3-hydroxyphenyl)acetamide

HRID 26671

Reaction equation

HRID 26671 reaction equation
[C:1]1([O:7]C)C=CC=CC=1.[C:9]([NH:12][C:13]1[CH:14]=[C:15]([OH:19])[CH:16]=[CH:17][CH:18]=1)(=[O:11])[CH3:10]>>[OH:19][C:15]1[CH:14]=[C:13]([NH:12][C:9](=[O:11])[CH3:10])[CH:18]=[CH:17][C:16]=1[CH:1]=[O:7]

Participants

3

Reactant 2

HCID 7519AnisoleHCID 121243-Hydroxyacetanilide

Product 1

HCID 12264699N-(4-formyl-3-hydroxyphenyl)acetamide

Procedure

By operating according to Example 13, but using anisole as the solvent and a temperature of 100° C., and starting from 15.1 g of 3-acetylaminophenol, 9.0 g of a product (yield on the theoretical value=50%) having a melting point at 185°-186° C. were obtained.

Workup

  1. customa temperature of 100° C.
  2. customyield on the theoretical value=50%)
  3. customat 185°-186° C.
  4. customwere obtained

Sources & evidence

ORD record
ord-21f595ce2255497e8b72055a7472fa8b
Source dataset
uspto-grants-1979_04
Patent number
US04151201

Linked notes

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