HomeMCPWorkbenchSkills
HomeWorkbenchNotificationsMe
llms.txt · MCP GuidePrivacy Policy · Terms of Service · Supportv1.8.0
  1. Home
  2. /Reaction

Tyramine → Biotin tyramine

HRID 2681
Notes
Print preview

Reaction equation

HRID 2681 reaction equation
ON1C(=O)CCC1=O.[OH:9][C:10]([CH2:12][CH2:13][CH2:14][CH2:15][C@H:16]1[C@@H:24]2[C@@H:19]([NH:20][C:21]([NH:23]2)=[O:22])[CH2:18][S:17]1)=[O:11].[NH2:25][CH2:26][CH2:27][C:28]1[CH:33]=[CH:32][C:31]([OH:34])=[CH:30][CH:29]=1.C(=O)(O)[O-].C([NH+](CC)CC)C>CN(C)C=O>[OH:11][C:10]([CH2:12][CH2:13][CH2:14][CH2:15][C@H:16]1[C@@H:24]2[C@@H:19]([NH:20][C:21]([NH:23]2)=[O:22])[CH2:18][S:17]1)=[O:9].[NH2:25][CH2:26][CH2:27][C:28]1[CH:33]=[CH:32][C:31]([OH:34])=[CH:30][CH:29]=1
ParticipantsConditionsProcedureSources & evidenceReaction notes

Participants

5

Reactant 3

HCID 5610TyramineHCID 11768884Triethylammonium hydrogen carbonateHCID 86743017n-Hydroxysuccinimide biotin

Product 1

HCID 86746652Biotin tyramine

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
50 °C

Procedure

a solution of biotin-N-hydroxysuccinimide, 170 mg (0.5 mMoles), and tyramine (recrystallized from water), 68.5 mg (0.5 mMoles), in 25 ml dimethylformamide was treated with 10 ml of 1M triethylammonium bicarbonate, pH 7.5, and then heated at 50° C. for 3 hours.

Sources & evidence

ORD record
ord-989c68d91dfc4d74a9b62cfdff0165f9
Source dataset
uspto-grants-1998_03
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US05731158

Reaction notes

Loading…

On this pageParticipantsConditionsProcedureSources & evidenceReaction notes