Hydrogen Bromide → HCID 178419247, compound
Reaction equation
Cl.O[CH2:3][C:4]1[N:5]=[CH:6][NH:7][C:8]=1[CH3:9].Cl.[NH2:11][CH2:12][CH2:13][SH:14].[BrH:15]>C(O)(=O)C>[BrH:15].[BrH:15].[CH3:9][C:8]1[N:7]=[CH:6][NH:5][C:4]=1[CH2:3][S:14][CH2:13][CH2:12][NH2:11]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of 4-hydroxymethyl-5-methylimidazole hydrochloride (15.0 g.), cysteamine hydrochloride (11.5 g.) and a solution of hydrogen bromide in acetic acid (48%, 225 ml.) was heated under reflux for 7 hours. Cooling afforded 4-methyl-5-[(2-aminoethyl)thiomethyl]imidazole dihydrobromide (21.6 g.), m.p. 208°-211°.
Workup
- temperatureunder reflux for 7 hours
- temperatureCooling
Sources & evidence
- ORD record
- ord-09b2f68b6cbf45809cb4f9118f470b60
- Source dataset
- uspto-grants-1979_04
- Patent number
- US04151288
Reaction notes
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