Hydrochloric Acid → Methyl 3-(sec-butylcarbamoyl)acrylate

HRID 269713

Reaction equation

[CH:1]([NH:5][C:6]([CH:8]=[CH:9][C:10]([OH:12])=[O:11])=[O:7])([CH2:3][CH3:4])[CH3:2].Cl.[CH3:14]O>>[CH:1]([NH:5][C:6]([CH:8]=[CH:9][C:10]([O:12][CH3:14])=[O:11])=[O:7])([CH2:3][CH3:4])[CH3:2]

Participants

Reactant 3

HCID 313Hydrochloric Acid

HCID 887Methanol

HCID 2445953-(Sec-butylcarbamoyl)acrylic acid

Product 1

HCID 54128810Methyl 3-(sec-butylcarbamoyl)acrylate

Procedure

To 3-(sec butylcarbamoyl)acrylic acid (20 g, 117 mmol) at room temperature was added 150 mL 1.2M HCl in methanol. The resulting mixture was stirred for two hours. Solvents were removed in vacuo to give the desired ester, which was used without further purification.

Workup

customSolvents were removed in vacuo

Sources & evidence

ORD record: ord-4c7dd66728e1478c8e5011a149f328cd
Source dataset: uspto-grants-2008_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07449242B2

Linked notes

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