Trifluoroacetic acid → Morpholin-2-ylmethyl trifluoroacetate

HRID 270107

Reaction equation

HRID 270107 reaction equation
[OH:1][CH2:2][CH:3]1[O:8][CH2:7][CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4]1.[C:16]([C:20](O)=[O:21])([F:19])([F:18])[F:17]>C(Cl)Cl>[F:17][C:16]([F:19])([F:18])[C:20]([O:1][CH2:2][CH:3]1[O:8][CH2:7][CH2:6][NH:5][CH2:4]1)=[O:21]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 5201202tert-Butyl 2-(hydroxymethyl)morpholine-4-carboxylate

Product 1

HCID 11206644Morpholin-2-ylmethyl trifluoroacetate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Tert-Butyl 2-(hydroxymethyl)-4-morpholinecarboxylate (5.13 g, 23.61 mmol) was treated with CF3CO2H (20 mL) in CH2Cl2 (50 mL) at room temperature for 3 h. The volatiles were removed in vacuo to give the subtitled compound (7.6 g).

Workup

  1. customThe volatiles were removed in vacuo

Sources & evidence

ORD record
ord-cd13a1f2c918407faf5b11bd981b00ae
Source dataset
uspto-grants-2008_11
Patent number
US07449475B2

Linked notes

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