Boron trifluoride etherate → HCID 178505646, compound

HRID 270782

Reaction equation

HRID 270782 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([F:9])[CH:4]=1)#[CH:2].[Li]CCCC.[C:15]([C:19](OCC)=O)([F:18])([F:17])[F:16].B(F)(F)F.O(CC)CC.[NH2:33][NH2:34]>C1COCC1.C1C=CC=CC=1>[F:9][C:5]1[CH:4]=[C:3]([C:1]2[NH:34][N:33]=[C:19]([C:15]([F:18])([F:17])[F:16])[CH:2]=2)[CH:8]=[CH:7][CH:6]=1

Participants

8

Reactant 5

HCID 8000Boron trifluoride etherateHCID 9321HydrazineHCID 9794Ethyl trifluoroacetateHCID 5202181-Ethynyl-3-fluorobenzeneHCID 178418339Butyllithium

Product 1

HCID 178505646HCID 178505646, compound

Reagents, catalysts & solvents 2

HCID 241BenzeneSolventHCID 8028TetrahydrofuranSolvent

Procedure

Following protocol H, 1-Ethynyl-3-fluoro-benzene was treated with n-BuLi, CF3CO2Et and BF3—OEt2 in THF. Reaction with hydrazine in benzene under similar reaction conditions yielded title compound.

Workup

  1. customunder similar reaction conditions

Sources & evidence

ORD record
ord-d8bdb191e76f452697277aaab9a78660
Source dataset
uspto-grants-2008_11
Patent number
US07449576B1

Linked notes

Loading…