Dichloromethane → 2-Chloro-1-(4-(4-chloro-3-methoxyphenyl)piperazin-1-yl)ethanone
Reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[CH:4][C:3]=1[O:14][CH3:15].CCN(CC)CC.[Cl:23][CH2:24][C:25](Cl)=[O:26].C(Cl)Cl>CCCCCC.C(OCC)(=O)C>[Cl:23][CH2:24][C:25]([N:11]1[CH2:10][CH2:9][N:8]([C:5]2[CH:6]=[CH:7][C:2]([Cl:1])=[C:3]([O:14][CH3:15])[CH:4]=2)[CH2:13][CH2:12]1)=[O:26]Participants
6
Procedure
Protocol S was followed using 1-(4-chloro-3-methoxyphenyl) piperazine, Et3N, chloroacetyl chloride and methylene chloride. Column chromatography using a solvent mixture (hexane/ethyl acetate=1.5/1) afforded the title compounds as a white solid
Sources & evidence
- ORD record
- ord-5c244e2cb0bf40d7992f3c34107868a9
- Source dataset
- uspto-grants-2008_11
- Patent number
- US07449576B1
Reaction notes
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