Dichloromethane → 2-Chloro-1-[4-(4-bromo-3-methoxy-phenyl)-piperazin-1-yl]-ethanone

HRID 270852

Reaction equation

HRID 270852 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[CH:4][C:3]=1[O:14][CH3:15].CCN(CC)CC.[Cl:23][CH2:24][C:25](Cl)=[O:26].C(Cl)Cl>CCCCCC.C(OCC)(=O)C>[Cl:23][CH2:24][C:25]([N:11]1[CH2:10][CH2:9][N:8]([C:5]2[CH:6]=[CH:7][C:2]([Br:1])=[C:3]([O:14][CH3:15])[CH:4]=2)[CH2:13][CH2:12]1)=[O:26]

Participants

6

Reactant 4

HCID 6344DichloromethaneHCID 6577Chloroacetyl chlorideHCID 8471TriethylamineHCID 210710161-(4-Bromo-3-methoxyphenyl)piperazine

Product 1

HCID 210711252-Chloro-1-[4-(4-bromo-3-methoxy-phenyl)-piperazin-1-yl]-ethanone

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

Protocol S was followed using 1-(4-bromo-3-methoxyphenyl) piperazine, Et3N, chloroacetyl chloride and methylene chloride. Column chromatography using a solvent mixture (hexane/ethyl acetate=1.5/1) afforded the title compounds as a white solid

Sources & evidence

ORD record
ord-5cbc3feeb2074068925eee7be2fe0c68
Source dataset
uspto-grants-2008_11
Patent number
US07449576B1

Linked notes

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