Aniline → 2-[(N-phenylcarbamoyl)methyl]prop-2-enoic acid
Reaction equation
[CH2:1]=[C:2]1[CH2:7][C:6](=[O:8])[O:5][C:3]1=[O:4].[NH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>CCl>[C:10]1([NH:9][C:6]([CH2:7][C:2](=[CH2:1])[C:3]([OH:5])=[O:4])=[O:8])[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of 2-methylenesuccinic anhydride (500 mg, 4.46 mmol) and aniline (0.4 mL, 4.46 mmol) in CH3Cl were shaken overnight. A precipitate formed, which was filtered off, washed with hexanes, and dried under vacuum to afford 2-[(N-phenylcarbamoyl)methyl]prop-2-enoic acid.
Workup
- customA precipitate formed
- filtrationwhich was filtered off
- washwashed with hexanes
- customdried under vacuum
Sources & evidence
- ORD record
- ord-682c33e9511d4681b3e6095fa4659f39
- Source dataset
- uspto-grants-2008_11
- Patent number
- US07452889B2
Reaction notes
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