1-(2,6-Dichlorophenyl)3-(t-butylcarbamyl)thiourea → 1-(2,6-Dichlorophenyl)-3-carbamylthiourea
Reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[NH:9][C:10]([NH:12][C:13](=[O:19])[NH:14]C(C)(C)C)=[S:11]>Cl>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[NH:9][C:10]([NH:12][C:13](=[O:19])[NH2:14])=[S:11]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of 32 g (0.1 mole) of 1-(2,6-dichlorophenyl)3-(t-butylcarbamyl)thiourea and 200 ml of conc. hydrochloric acid is refluxed for 1/2 hour. The reaction mixture is cooled, filtered and washed with 10 ml of 1:1 HCl/H2O and dried. The product is then recrystallized from ethanolether to obtain 1-(2,6-dichlorophenyl)-3-carbamylthiourea.
Workup
- temperatureis refluxed for 1/2 hour
- temperatureThe reaction mixture is cooled
- filtrationfiltered
- washwashed with 10 ml of 1:1 HCl/H2O
- customdried
- customThe product is then recrystallized from ethanolether
Sources & evidence
- ORD record
- ord-d9aba9dc1f5342419a7a05c7b9e05b13
- Source dataset
- uspto-grants-1980_09
- Patent number
- US04220658
Reaction notes
Loading…