Propargylamine → HCID 178457545, compound

HRID 27392

Reaction equation

HRID 27392 reaction equation
CS[C:3](SC)=[C:4](C(OC)=O)[C:5]#[N:6].CC1N=CNC=1CSCCN.[C:24]([C:28]([C:43]#[N:44])=[C:29](SC)[NH:30][CH2:31][CH2:32][S:33][CH2:34][C:35]1[NH:39][CH:38]=[N:37][C:36]=1[CH3:40])([O:26][CH3:27])=[O:25].C(N)C#C>>[C:24]([C:28]([C:43]#[N:44])=[C:29]([NH:6][CH2:5][C:4]#[CH:3])[NH:30][CH2:31][CH2:32][S:33][CH2:34][C:35]1[NH:39][CH:38]=[N:37][C:36]=1[CH3:40])([O:26][CH3:27])=[O:25]

Participants

5

Reactant 4

HCID 239041PropargylamineHCID 319957Methyl 2-cyano-3,3-bis(methylsulfanyl)prop-2-enoateHCID 178433288HCID 178433288, compoundHCID 178500817HCID 178500817, compound

Product 1

HCID 178457545HCID 178457545, compound

Procedure

When 1,1-bis(methylthio)-2-carbomethoxy-2-cyanoethylene [prepared according to the procedure described in Chem. Ber., 95, 2861 (1962)] is reacted with 2-[(4-methyl-1H-imidazol-5-yl)methylthio]ethylamine according to the procedure of Example 6, Step A, and the resultant 1-carbomethoxy-1-cyano-2-methylthio-2-{2-[(4-methyl-1H-imidazol-5-yl)-methylthio]ethylamino}ethylene treated with propargylamine by the procedure of Example 6, Step B, there is produced 1-carbomethoxy-1-cyano-2-(2-propynylamino)-2-{2-[(4-methyl-1H-imidazol-5-yl)methylthio]ethylamino}ethylene.

Sources & evidence

ORD record
ord-24a9e30174db480490dec92e911d3247
Source dataset
uspto-grants-1980_09
Patent number
US04221737

Linked notes

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