4,5-Diaminopyrimidine → HCID 178441557, compound

HRID 274330

Reaction equation

HRID 274330 reaction equation
[NH2:1][C:2]1[C:7]([NH2:8])=[CH:6][N:5]=[CH:4][N:3]=1.Cl.[C:10](=N)(OCC)[CH2:11][CH2:12][CH2:13][CH3:14]>CN(C)C=O>[CH2:11]([C:10]1[NH:1][C:2]2[N:3]=[CH:4][N:5]=[CH:6][C:7]=2[N:8]=1)[CH2:12][CH2:13][CH3:14]

Participants

4

Reactant 2

HCID 837034,5-DiaminopyrimidineHCID 12283341Ethyl pentanimidate hydrochloride

Product 1

HCID 178441557HCID 178441557, compoundYield 26.2%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Using the procedure of Example 1, 5 g of 4,5-diaminopyrimidine and 10 g of ethyl pentanimidoate hydrochloride [J.A.C.S., Vol. 64, p 1827 (1942)] using dimethylformamide as solvent were reacted to obtain 2.1 g of the desired product which after crystallization from ethyl acetate melted at 166° C. The product was crystallized from ethyl acetate to obtain 1.8 g of the expected product melting at 168° C. 200 mg of an analytical sample was obtained by an additional crystallization of 300 mg of the product from ethyl acetate melting at 168° C.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-210f4d400a3b450da44784244e0b5696
Source dataset
uspto-grants-1995_02
Patent number
US05389634

Linked notes

Loading…