Hydroxyamine hydrochloride → 2-Chloro-3-hydroxy-p-anisaldehyde oxime
Reaction equation
[Cl:1][C:2]1[C:9]([OH:10])=[C:8]([O:11][CH3:12])[CH:7]=[CH:6][C:3]=1[CH:4]=O.Cl.[NH2:14][OH:15]>C(O)C>[Cl:1][C:2]1[C:9]([OH:10])=[C:8]([O:11][CH3:12])[CH:7]=[CH:6][C:3]=1[CH:4]=[N:14][OH:15]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of 30 g of 2-chloro-3-hydroxy-p-anisaldehyde and 230 ml of ethanol is stirred at 70° for 4 hours in the presence of 12.3 g of hydroxylamine hydrochloride, the reaction mixture is subsequently evaporated the residue is dried in a high vacuum and recrystallized from methanol/water. There is obtained 2-chloro-3-hydroxy-p-anisaldehyde oxime of m.p. 174°-176°.
Workup
- customthe reaction mixture is subsequently evaporated the residue
- customis dried in a high vacuum
- customrecrystallized from methanol/water
Sources & evidence
- ORD record
- ord-455db7c198324923a0023d593d80a4d1
- Source dataset
- uspto-grants-1995_02
- Patent number
- US05389653
Reaction notes
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