Hydrogen Bromide → HCID 178419246, compound

HRID 27486

Reaction equation

HRID 27486 reaction equation
[CH2:1]([CH2:4][SH:5])[CH2:2][NH2:3].Cl.Cl.O[CH2:9][C:10]1[N:11]=[CH:12][NH:13][C:14]=1[CH3:15].[BrH:16]>>[BrH:16].[BrH:16].[CH3:15][C:14]1[N:13]=[CH:12][NH:11][C:10]=1[CH2:9][S:5][CH2:4][CH2:1][CH2:2][NH2:3]

Participants

4

Reactant 3

HCID 260Hydrogen BromideHCID 197870(3-Mercaptopropyl)ammonium chlorideHCID 30847074-Methylimidazol-5-ylmethanolhydrochloride

Product 1

HCID 178419246HCID 178419246, compound

Procedure

A solution of homocysteamine hydrochloride (22.0 g.) and 4-hydroxymethyl-5-methylimidazole hydrochloride (25.6 g.) in aqueous hydrobromic acid (500 ml.) was heated under reflux for one hour. Concentration under reduced pressure, followed by recrystallisation from methanol-isopropyl alcohol afforded 4-methyl-5-[(3-aminopropyl)thiomethyl]-imidazole dihydrobromide (24.5 g.), m.p. 200.5°-202.5°.

Workup

  1. temperatureunder reflux for one hour
  2. concentrationConcentration under reduced pressure
  3. customfollowed by recrystallisation from methanol-isopropyl alcohol

Sources & evidence

ORD record
ord-0f741a2a5c06423e9b5b3ae11f839319
Source dataset
uspto-grants-1980_09
Patent number
US04221802

Linked notes

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