1,3-Propanediamine → N-(3-aminopropyl)pyrimidin-2-amine

HRID 27522

Reaction equation

HRID 27522 reaction equation
Br[C:2]1[N:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[NH2:8][CH2:9][CH2:10][CH2:11][NH2:12].[O-]CC.[Na+]>C(O)C>[NH2:8][CH2:9][CH2:10][CH2:11][NH:12][C:2]1[N:7]=[CH:6][CH:5]=[CH:4][N:3]=1

Participants

5

Reactant 3

HCID 4281,3-PropanediamineHCID 783452-BromopyrimidineHCID 2723922Sodium ethoxide

Product 1

HCID 14397405N-(3-aminopropyl)pyrimidin-2-amine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Reaction of 2-bromopyrimidine with 1,3-diaminopropane in ethanol containing sodium ethoxide gives 2-(3-aminopropylamino)pyrimidine.

Sources & evidence

ORD record
ord-c0b38f0dc52c497c96c45df8e556147c
Source dataset
uspto-grants-1980_09
Patent number
US04221802

Linked notes

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