1,3-Propanediamine → 3-(3-Aminopropylamino)pyridazine

HRID 27531

Reaction equation

HRID 27531 reaction equation
Cl[C:2]1[N:3]=[N:4][CH:5]=[CH:6][CH:7]=1.[NH2:8][CH2:9][CH2:10][CH2:11][NH2:12].[O-]CC.[Na+]>C(O)C>[NH2:8][CH2:9][CH2:10][CH2:11][NH:12][C:2]1[N:3]=[N:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 4281,3-PropanediamineHCID 2723922Sodium ethoxideHCID 112749893-Chloropyridazine

Product 1

HCID 186942073-(3-Aminopropylamino)pyridazine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Reacting 3-chloropyridazine with 1,3-diaminopropane in ethanol containing sodium ethoxide according to the procedure of Example 89 gives 3-(3-aminopropylamino)-pyridazine. Using this intermediate as the starting material in the procedure of Example 18 gives N-cyano-N'-[3-(3-pyridazinylamino)propyl]guanidine.

Sources & evidence

ORD record
ord-7c20833f40fc4db68c319b125065566f
Source dataset
uspto-grants-1980_09
Patent number
US04221802

Linked notes

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