Cysteamine → 3-[(2-Aminoethyl)thiomethyl]-5-chloro-1,2,4-thiadiazole

HRID 27564

Reaction equation

[Cl:1][C:2]1[S:6][N:5]=[C:4]([CH2:7]Cl)[N:3]=1.[NH2:9][CH2:10][CH2:11][SH:12]>>[NH2:9][CH2:10][CH2:11][S:12][CH2:7][C:4]1[N:3]=[C:2]([Cl:1])[S:6][N:5]=1

Participants

Reactant 2

HCID 6058Cysteamine

HCID 3326105-Chloro-3-(chloromethyl)-1,2,4-thiadiazole

Product 1

HCID 205674873-[(2-Aminoethyl)thiomethyl]-5-chloro-1,2,4-thiadiazole

Procedure

Reacting 5-chloro-3-chloromethyl-1,2,4-thiadiazole with cysteamine by the procedure of Example 1(i)(c) gives 3-[(2-aminoethyl)thiomethyl]-5-chloro-1,2,4-thiadiazole.

Sources & evidence

ORD record: ord-37c70aebcb44441a85bf82b0cd8f0819
Source dataset: uspto-grants-1980_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04221802

Linked notes

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