2-Chloropropionic acid → 2-(2-methyl-4-nitrophenylimino)-3-((1S)-1-cyclohexylethyl)-5-methyl-1,3-thiazolidin-4-one

HRID 276676

Reaction equation

HRID 276676 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:4][C:3]=1[N:11]=[C:12]=[S:13].[NH2:14][C@H:15]([CH:17]1[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1)[CH3:16].Cl[CH:24]([CH3:28])[C:25](O)=[O:26]>>[CH3:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:4][C:3]=1[N:11]=[C:12]1[N:14]([C@H:15]([CH:17]2[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]2)[CH3:16])[C:25](=[O:26])[CH:24]([CH3:28])[S:13]1

Participants

4

Reactant 3

HCID 117342-Chloropropionic acidHCID 1456212-Methyl-4-nitrophenyl isothiocyanateHCID 5325951(S)-(+)-1-Cyclohexylethylamine

Product 1

HCID 229512212-(2-methyl-4-nitrophenylimino)-3-((1S)-1-cyclohexylethyl)-5-methyl-1,3-thiazolidin-4-one

Procedure

2-Methyl-4-nitrophenyl isothiocyanate was reacted with (1S)-1-amino-1-cyclohexylethane followed by α-chloropropionic acid according to Method C8a to afford 2-(2-methyl-4-nitrophenylimino)-3-((1S)-1-cyclohexylethyl)-5-methyl-1,3-thiazolidin4-one.

Sources & evidence

ORD record
ord-a3321bbe513340c99efa429a99565c33
Source dataset
uspto-grants-2002_03
Patent number
US06353006B1

Linked notes

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