Ethyl Acetate → (Pentafluorophenyl)glycolic acid

HRID 277924

Reaction equation

[F:1][C:2]1[C:9]([F:10])=[C:8]([F:11])[C:7]([F:12])=[C:6]([F:13])[C:3]=1[CH:4]=[O:5].C[C:15](=[O:19])[O:16]CC>>[F:1][C:2]1[C:9]([F:10])=[C:8]([F:11])[C:7]([F:12])=[C:6]([F:13])[C:3]=1[CH:4]([OH:5])[C:15]([OH:19])=[O:16]

Participants

Reactant 2

HCID 8857Ethyl Acetate

HCID 69558Pentafluorobenzaldehyde

Product 1

HCID 102460(Pentafluorophenyl)glycolic acid

Procedure

The 2,3,4,5,6-pentafluorobenzaldehyde (49.4 g, 252 mmol) was converted to product in a manner substantially analogous to Preparation 59 to yield 52.3 g. (86.0). EA, MS(FD).

Workup

customto yield 52.3 g

Sources & evidence

ORD record: ord-6b8ec89966a54e18935f111a0d5cad1f
Source dataset: uspto-grants-2002_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06358971B1

Linked notes

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