4-Chlorobenzaldehyde → E-4-chlorostyryl 4-chlorobenzyl sulfone

Reaction equation

[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([CH2:6][S:7]([CH2:10][C:11](O)=O)(=[O:9])=[O:8])=[CH:4][CH:3]=1.[Cl:16][C:17]1[CH:24]=[CH:23][C:20](C=O)=[CH:19][CH:18]=1>>[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([CH2:6][S:7](/[CH:10]=[CH:11]/[C:20]2[CH:23]=[CH:24][C:17]([Cl:16])=[CH:18][CH:19]=2)(=[O:9])=[O:8])=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 77264-Chlorobenzaldehyde

HCID 302767[(4-Chlorobenzyl)sulfonyl]acetic acid

Product 1

HCID 9862179E-4-chlorostyryl 4-chlorobenzyl sulfoneYield 80%

Procedure

A solution of 4-chlorobenzyl sulfonylacetic acid (0.01 mol) and 4-chlorobenzaldehyde (0.01 mol) was subjected to Procedure 1. The title compound was obtained in 80% yield.

Sources & evidence

ORD record: ord-749d57c21a51493c928c77924660aa65
Source dataset: uspto-grants-2002_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06359013B1

Reaction notes

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