Pivalic acid → n-Neopentanoyl-2-butyloctylamine

HRID 278531Notes

Reaction equation

HRID 278531 reaction equation
[C:1]([OH:7])(=O)[C:2]([CH3:5])([CH3:4])[CH3:3].[CH2:8]([CH:12]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])[CH2:13][NH2:14])[CH2:9][CH2:10][CH3:11]>CCCCCCC>[C:1]([NH:14][CH2:13][CH:12]([CH2:8][CH2:9][CH2:10][CH3:11])[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])(=[O:7])[C:2]([CH3:5])([CH3:4])[CH3:3]

Participants

4

Reactant 2

HCID 6417Pivalic acidHCID 186732842-Butyl-n-octan-1-amine

Product 1

HCID 18673286n-Neopentanoyl-2-butyloctylamineYield 76%

Reagents, catalysts & solvents 1

HCID 8900HeptaneSolvent

Procedure

10.4 g of pivalic acid and 17.2 g of 2-butyloctylamine were mixed together in the tube of a microwave machine (Maxidigest™ MX 350 from the company Prolabo; frequency 2450±50 MHz, modulable power 300 W). After irradiation for about 1 hour at 160° C.±10° C., the reaction mixture was dissolved in heptane and then purified on silica. 19 g of the desired amide were obtained.

Workup

  1. customAfter irradiation for about 1 hour at 160° C.±10° C.
  2. custompurified on silica

Sources & evidence

ORD record
ord-8b27d062e00d4dcfacb35b68adc53cff
Source dataset
uspto-grants-2002_03
Patent number
US06359175B1

Reaction notes

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