Methanol → HCID 10270267, compound

HRID 278664

Reaction equation

HRID 278664 reaction equation
C([O:3][C:4](=[O:29])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]#[C:13][C:14]2[CH:15]=[C:16]3[C:21](=[CH:22][CH:23]=2)[O:20][C:19]([CH3:25])([CH3:24])[CH2:18][C:17]3([CH3:27])[CH3:26])=[CH:8][C:7]=1[F:28])C.CO.[OH-].[Na+].C(OCC)(=O)C>CCCCCC>[F:28][C:7]1[CH:8]=[C:9]([C:12]#[C:13][C:14]2[CH:15]=[C:16]3[C:21](=[CH:22][CH:23]=2)[O:20][C:19]([CH3:25])([CH3:24])[CH2:18][C:17]3([CH3:26])[CH3:27])[CH:10]=[CH:11][C:6]=1[CH2:5][C:4]([OH:29])=[O:3]

Participants

6

Reactant 4

HCID 887MethanolHCID 8857Ethyl AcetateHCID 14798Sodium HydroxideHCID 69548829[2-Fluoro-4-(2,2,4,4-tetramethyl-chroman-6-ylethynyl) phenyl]acetic acid ethyl ester2×

Product 1

HCID 10270267HCID 10270267, compound

Reagents, catalysts & solvents 1

HCID 8058HexaneSolvent

Procedure

Following general procedure L and using [2-fluoro-4-(2,2,4,4-tetramethyl-chroman-6-ylethynyl) phenyl] acetic acid ethyl ester (Compound 31, 0.2 1 g, 0.58 mmol), 5 mL of methanol and 1M sodium hydroxide solution (2 mL) followed by flash column chromatography over silica gel (230-400 mesh) using 50% ethyl acetate in hexane, the title compound was obtained as a solid (0.184 g, 93%).

Sources & evidence

ORD record
ord-5190a76fce00448d9366a9c98dde701a
Source dataset
uspto-grants-2002_03
Patent number
US06359135B1

Linked notes

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