Tetrafluoroisophthalic Acid → HCID 10130865, compound
Reaction equation
F[C:2]1[C:7]([C:8]([OH:10])=[O:9])=[C:6]([F:11])[C:5]([C:12]([OH:14])=[O:13])=[C:4]([F:15])[C:3]=1[F:16].[CH3:17][Mg]Cl>C1COCC1>[F:11][C:6]1[C:5]([C:12]([OH:14])=[O:13])=[C:4]([F:15])[C:3]([F:16])=[C:2]([CH3:17])[C:7]=1[C:8]([OH:10])=[O:9]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
20 g of tetrafluoroisophthalic acid are initially charged in 250 ml of THF and, at from 20 to 40° C., admixed with 88 ml of a 3 molar methylmagnesium chloride solution. Customary aqueous work-up (see Example 3) gives 20.1 g of 2,4,5-trifluoro-6-methylisophthalic acid. The purity of the product is 85% by HPLC.
Sources & evidence
- ORD record
- ord-77d6ae5fa95046f9b9314c9da16b70f2
- Source dataset
- uspto-grants-2002_03
- Patent number
- US06362365B1
Reaction notes
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