2-Chloro-4-nitropyridine 1-oxide → Pyridine, 2-chloro-4-methoxy-, 1-oxide

HRID 279834

Reaction equation

HRID 279834 reaction equation
[Na].[CH3:2][O-:3].[Na+].[Cl:5][C:6]1[CH:11]=[C:10]([N+]([O-])=O)[CH:9]=[CH:8][N+:7]=1[O-:15]>CO>[Cl:5][C:6]1[CH:11]=[C:10]([O:3][CH3:2])[CH:9]=[CH:8][N+:7]=1[O-:15]

Participants

5

Reactant 3

HCID 844332-Chloro-4-nitropyridine 1-oxideHCID 5360545SodiumHCID 10942334Sodium Methoxide

Product 1

HCID 15593755Pyridine, 2-chloro-4-methoxy-, 1-oxide

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

Sodium (0.46 g) is dissolved in absolute methanol (50 ml) and the resultant solution of sodium methoxide is added to a solution of 2-chloro-4-nitropyridine-1-oxide (3.5 g, prepared as described in Example 1) in methanol (10 ml). The reaction mixture is allowed to stand at room temperature for 50 hours and is then subjected to rotary evaporation to give 2-chloro-4-methoxypyridine-1-oxide.

Workup

  1. customis then subjected to rotary evaporation

Sources & evidence

ORD record
ord-20c5b2c1ecd64b7c88f1f08ccc54e6e7
Source dataset
uspto-grants-1986_05
Patent number
US04587240

Linked notes

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