Dimethylformamide → HCID 178508798, compound

HRID 27986

Reaction equation

HRID 27986 reaction equation
Cl[CH2:2][CH2:3][N:4]=[C:5]=[S:6].[C:7]([NH:10][C:11]([C:13]1[C:18]([NH2:19])=[N:17][C:16]([NH2:20])=[C:15]([Cl:21])[N:14]=1)=[O:12])(=N)[NH2:8].C[N:23](C=O)C>>[NH2:19][C:18]1[C:13]([C:11]([N:10]=[CH:7][NH:8][NH:23][C:5]2[S:6][CH2:2][CH2:3][N:4]=2)=[O:12])=[N:14][C:15]([Cl:21])=[C:16]([NH2:20])[N:17]=1

Participants

4

Reactant 3

HCID 6228DimethylformamideHCID 1386612-Chloroethyl IsothiocyanateHCID 178513083HCID 178513083, compound

Product 1

HCID 178508798HCID 178508798, compound

Procedure

2-Chloroethylisothiocyanate (670 mg., 0.0055 mole) is added to a warm (40° C.) solution of N-amidino 3,5-diamino-6-chloro-2-pyrazinecarboxamide (1.15 g., 0.005 mole) in DMF (30 ml.) with stirring. After 2 hours, the solid precipitate is collected, washed with H2 0 and dried to give 3,5-diamino-6-chloro-N-[(2-thiazolinylamino)aminomethylene]-2-pyrazinecarboxamide., m.p. 252°-254° C.

Workup

  1. customthe solid precipitate is collected
  2. washwashed with H2 0
  3. customdried

Sources & evidence

ORD record
ord-92a69fa679e14afdaa50b2bc425f669f
Source dataset
uspto-grants-1980_09
Patent number
US04224447

Linked notes

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