1,1'-Carbonyldiimidazole → 5-Pyrimidyl carboxylic acid imidazolide

HRID 280244

Reaction equation

HRID 280244 reaction equation
[N:1]1[CH:6]=[C:5]([C:7]([OH:9])=[O:8])[CH:4]=[N:3][CH:2]=1.C(N1C=CN=C1)(N1C=CN=C1)=O>C(Cl)Cl>[N-:3]1[CH:5]=[CH:6][N:1]=[CH:2]1.[N:1]1[CH:6]=[C:5]([C:7]([OH:9])=[O:8])[CH:4]=[N:3][CH:2]=1

Participants

4

Reactant 2

HCID 682631,1'-CarbonyldiimidazoleHCID 78346Pyrimidine-5-carboxylic acid

Product 1

HCID 867399665-Pyrimidyl carboxylic acid imidazolide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

5-pyrimidyl carboxylic acid, 1.9 gm, was added to 30 ml of methylene chloride. 2.4 gm of carbonyldiimidazole was added to the system. The system was stirred at room temperature for 3 hours to form the 5-pyrimidyl carboxylic acid imidazolide.

Sources & evidence

ORD record
ord-45c587997494432c87f23050fd22982c
Source dataset
uspto-grants-1986_05
Patent number
US04588735

Linked notes

Loading…