p-Toluenesulfonic acid → Cycloheptyl-2-mercaptopropionate

HRID 280501

Reaction equation

HRID 280501 reaction equation
[CH:1]1([OH:8])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[SH:9][CH:10]([CH3:14])[C:11](O)=[O:12].C1(C)C=CC(S(O)(=O)=O)=CC=1>>[CH:1]1([O:8][C:11](=[O:12])[CH:10]([SH:9])[CH3:14])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 3

HCID 6101p-Toluenesulfonic acidHCID 10399CycloheptanolHCID 62326(+-)-2-Mercaptopropionic acid

Product 1

HCID 20212360Cycloheptyl-2-mercaptopropionate

Procedure

Reaction: ##STR128## Into a 50 ml reaction flask equipped with stirrer, thermometer, reflux condenser and heating mantle are placed 11.4 grams cycloheptanol; 22 grams of 2-mercaptopropionic acid and 0.5 grams of paratoluene sulfonic acid. The reaction mass is heated to reflux and refluxed for a period of 10 hours. At the end of the 10 hour period, the reaction mass is distilled on a micro distillation apparatus to yield the compound having the structure: ##STR129##

Workup

  1. customReaction
  2. custom##STR128## Into a 50 ml reaction flask
  3. customequipped with stirrer
  4. temperaturethermometer, reflux condenser
  5. temperatureheating mantle
  6. temperatureThe reaction mass is heated
  7. temperatureto reflux
  8. temperaturerefluxed for a period of 10 hours
  9. distillationAt the end of the 10 hour period, the reaction mass is distilled on a micro distillation apparatus
  10. customto yield the compound

Sources & evidence

ORD record
ord-7865c488157c425f9ced1af031fe9972
Source dataset
uspto-grants-1986_05
Patent number
US04590082

Linked notes

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