Pyridine N-Oxide → 6-(Pyridin-2-yl)pyridazin-3-ol

HRID 280514

Reaction equation

HRID 280514 reaction equation
[N:1]1[NH:2][C:3](=[O:7])[CH:4]=[CH:5][CH:6]=1.[N+:8]1([O-])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>[Pd]>[N:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[C:6]1[CH:5]=[CH:4][C:3](=[O:7])[NH:2][N:1]=1

Participants

4

Reactant 2

HCID 12753Pyridine N-OxideHCID 681533(2H)-Pyridazinone

Product 1

HCID 49800226-(Pyridin-2-yl)pyridazin-3-ol

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Haginiwa et al. [Yakugaku Zasshi 98 (1), 67-71 (1978); Chem. Abstrs. 88, 170,096 v 1978) ] disclose the reaction of 3(2H)-pyridazinone with pyridine 1-oxide and platinized Pd-C catalyst to produce 6-(2-pyridinyl)-3(2H)-pyridazinone.

Sources & evidence

ORD record
ord-487d9a59529e4787970a0b30c16d13ce
Source dataset
uspto-grants-1986_05
Patent number
US04590194

Linked notes

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