2-Chlorobenzaldehyde → 2-(2'-Chlorostyryl)benzothiazole

Reaction equation

[Cl:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=O.[CH3:10][C:11]1[S:12][C:13]2[CH:19]=[CH:18][CH:17]=[CH:16][C:14]=2[N:15]=1.C(OC(=O)C)(=O)C>>[Cl:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=[CH:10][C:11]1[S:12][C:13]2[CH:19]=[CH:18][CH:17]=[CH:16][C:14]=2[N:15]=1

Participants

Reactant 3

HCID 69962-Chlorobenzaldehyde

HCID 7918Acetic Anhydride

HCID 84462-Methylbenzothiazole

Product 1

HCID 2792982-(2'-Chlorostyryl)benzothiazole

Procedure

The synthetic sequence commences with the condensation of a 2-chloro-benzaldehyde with 2-methylbenzothiazole II in boiling acetic anhydride to give 2-(2'-chlorostyryl)benzothiazole III.

Sources & evidence

ORD record: ord-5cb0eccd65d94ac9b36d422cb594f7e6
Source dataset: uspto-grants-1986_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04590275

Reaction notes

Loading…