3-Bromothiophene → 1-(2,4-Dimethyl-5-oxazolyl)-1-(3-thienyl)ethanol

Reaction equation

Br[C:2]1[CH:6]=[CH:5][S:4][CH:3]=1.[C:7]([C:10]1[O:14][C:13]([CH3:15])=[N:12][C:11]=1[CH3:16])(=[O:9])[CH3:8]>>[CH3:15][C:13]1[O:14][C:10]([C:7]([C:2]2[CH:6]=[CH:5][S:4][CH:3]=2)([OH:9])[CH3:8])=[C:11]([CH3:16])[N:12]=1

Participants

Reactant 2

HCID 133833-Bromothiophene

HCID 3184185-Acetyl-2,4-dimethyloxazole

Product 1

HCID 189363541-(2,4-Dimethyl-5-oxazolyl)-1-(3-thienyl)ethanol

Procedure

Starting with 3-bromothiophene and 5-acetyl-2,4-dimethyloxazole and following the general method of Example 4 the title compound was prepared. M.p. 132°-133° C.

Sources & evidence

ORD record: ord-a28e5022014c4c90b9d6d574f252284a
Source dataset: uspto-grants-1998_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05731335

Reaction notes

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