Trimethylsilylacetylene → 7-Difluoromethyl-5-(3-ethoxy-phenyl)-3-trimethylsilanylethynyl-pyrazolo[1,5-a]pyrimidine

Reaction equation

[Br:1][c:2]1[cH:3][n:4][n:5]2[c:6]1[n:7][c:8](-[c:14]1[cH:15][c:16]([O:20][CH2:21][CH3:22])[cH:17][cH:18][cH:19]1)[cH:9][c:10]2[CH:11]([F:12])[F:13].[CH3:23][Si:24]([CH3:25])([CH3:26])[C:27]#[CH:28]>>[c:2]1([C:28]#[C:27][Si:24]([CH3:23])([CH3:25])[CH3:26])[cH:3][n:4][n:5]2[c:6]1[n:7][c:8](-[c:14]1[cH:15][c:16]([O:20][CH2:21][CH3:22])[cH:17][cH:18][cH:19]1)[cH:9][c:10]2[CH:11]([F:12])[F:13]

Participants

Reactant 2

HCID 66111Trimethylsilylacetylene

HCID 670004273-Bromo-7-difluoromethyl-5-(3-ethoxy-phenyl)-pyrazolo[1,5-a]pyrimidine

Product 1

HCID 670003407-Difluoromethyl-5-(3-ethoxy-phenyl)-3-trimethylsilanylethynyl-pyrazolo[1,5-a]pyrimidine

Sources & evidence

ORD record: ord-dd7ccb68a80d428281f7b9d18fed1962
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (8/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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