Sodium Ion → 4-(Isoquinolin-4-yl)-4-hydroxypiperidine

Reaction equation

[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][C:11]([OH:14])([c:15]2[cH:16][n:17][cH:18][c:19]3[cH:20][cH:21][cH:22][cH:23][c:24]23)[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[Cl:32][CH2:33][Cl:34].[Na+:36].[OH-:35].[OH:25][C:26]([C:27]([F:28])([F:29])[F:30])=[O:31]>>[NH:8]1[CH2:9][CH2:10][C:11]([OH:14])([c:15]2[cH:16][n:17][cH:18][c:19]3[cH:20][cH:21][cH:22][cH:23][c:24]23)[CH2:12][CH2:13]1

Participants

Reactant 5

HCID 923Sodium Ion

HCID 961Hydroxide

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 177895011-Tert-butoxycarbon-yl-4-(isoquinolin-4-yl)-4-hydroxypiperidine

Product 1

HCID 211980184-(Isoquinolin-4-yl)-4-hydroxypiperidine

Sources & evidence

ORD record: ord-b8a21c9174d84fcd80dd8803f35d480f
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (8/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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