2-Acetylthiophene → 1-(4-Methyl-5-thiazolyl)-1-(2-thienyl)ethanol

Reaction equation

[CH3:1][C:2]1[N:3]=[CH:4][S:5][CH:6]=1.[C:7]([C:10]1[S:11][CH:12]=[CH:13][CH:14]=1)(=[O:9])[CH3:8]>>[CH3:1][C:2]1[N:3]=[CH:4][S:5][C:6]=1[C:7]([C:10]1[S:11][CH:12]=[CH:13][CH:14]=1)([OH:9])[CH3:8]

Participants

Reactant 2

HCID 69202-Acetylthiophene

HCID 127484-Methylthiazole

Product 1

HCID 189363081-(4-Methyl-5-thiazolyl)-1-(2-thienyl)ethanol

Procedure

Starting with 4-methylthiazole and 2-acetylthiophene and following the general method of Example 15 the title compound was prepared. M.p. 146.5°-147.5° C.

Sources & evidence

ORD record: ord-c5c6c64398c34e29931916d91cb3bfd4
Source dataset: uspto-grants-1998_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05731335

Reaction notes

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