Dichloromethane → 4-Chlorobenzylpiperazine

Reaction equation

[CH2:29]([Cl:30])[Cl:31].[Cl:8][c:9]1[cH:10][cH:11][c:12]([CH2:13][N:14]2[CH2:15][CH2:16][N:17]([C:20]([O:21][C:22]([CH3:23])([CH3:24])[CH3:25])=[O:26])[CH2:18][CH2:19]2)[cH:27][cH:28]1.[OH:1][C:2]([C:3]([F:4])([F:5])[F:6])=[O:7]>>[Cl:8][c:9]1[cH:10][cH:11][c:12]([CH2:13][N:14]2[CH2:15][CH2:16][NH:17][CH2:18][CH2:19]2)[cH:27][cH:28]1

Participants

Reactant 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 17723849Tert-butyl 4-(4-chlorobenzyl)piperazine-1-carboxylate

Product 1

HCID 1348264-Chlorobenzylpiperazine

Sources & evidence

ORD record: ord-bc1b422eeacf4a929bbee7bf84fb620b
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (8/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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