Dimethylamine → Dimethylacetoacetamide

HRID 2851

Reaction equation

HRID 2851 reaction equation
[CH2:1]=[C:2]1[O:6][C:4](=[O:5])[CH2:3]1.CC(C)=O.[CH3:11][NH:12][CH3:13]>C1(C)C=CC=CC=1>[CH3:11][N:12]([CH3:13])[C:4](=[O:5])[CH2:3][C:2](=[O:6])[CH3:1]

Participants

4

Reactant 2

HCID 674DimethylamineHCID 87118046Diketene acetone

Product 1

HCID 16278Dimethylacetoacetamide

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A solution of 9 ml (0.05 mmol) of diketene-acetone adduct in 20 ml of toluene was treated with gaseous dimethylamine at room temperature until the reaction was complete. The solvent was removed in vacuo and the residue was purified by chromatography on silica gel (EtOAc/MeOH 0%→10%) yielding 7.0 g of the title compound.

Workup

  1. customThe solvent was removed in vacuo
  2. customthe residue was purified by chromatography on silica gel (EtOAc/MeOH 0%→10%)

Sources & evidence

ORD record
ord-eb592b1203c74e969732293b7513ee02
Source dataset
uspto-grants-1998_03
Patent number
US05731322

Linked notes

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