Dimethylamine → Dimethylacetoacetamide
Reaction equation
[CH2:1]=[C:2]1[O:6][C:4](=[O:5])[CH2:3]1.CC(C)=O.[CH3:11][NH:12][CH3:13]>C1(C)C=CC=CC=1>[CH3:11][N:12]([CH3:13])[C:4](=[O:5])[CH2:3][C:2](=[O:6])[CH3:1]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of 9 ml (0.05 mmol) of diketene-acetone adduct in 20 ml of toluene was treated with gaseous dimethylamine at room temperature until the reaction was complete. The solvent was removed in vacuo and the residue was purified by chromatography on silica gel (EtOAc/MeOH 0%→10%) yielding 7.0 g of the title compound.
Workup
- customThe solvent was removed in vacuo
- customthe residue was purified by chromatography on silica gel (EtOAc/MeOH 0%→10%)
Sources & evidence
- ORD record
- ord-eb592b1203c74e969732293b7513ee02
- Source dataset
- uspto-grants-1998_03
- Patent number
- US05731322
Reaction notes
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