Dichloromethane → 5-(4-Aminomethyl-phenyl)-6-methoxy-nicotinonitrile

Reaction equation

[C:1]([O:2][C:3](=[O:4])[NH:7][CH2:8][c:9]1[cH:10][cH:11][c:12](-[c:15]2[c:16]([O:23][CH3:24])[n:17][cH:18][c:19]([C:21]#[N:22])[cH:20]2)[cH:13][cH:14]1)([CH3:5])([CH3:6])[CH3:25].[Cl:33][CH2:34][Cl:35].[OH:26][C:27]([C:28]([F:29])([F:30])[F:31])=[O:32]>>[NH2:7][CH2:8][c:9]1[cH:10][cH:11][c:12](-[c:15]2[c:16]([O:23][CH3:24])[n:17][cH:18][c:19]([C:21]#[N:22])[cH:20]2)[cH:13][cH:14]1

Participants

Reactant 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 67244354[4-(5-Cyano-2-methoxy-pyridin-3-yl)-benzyl]-carbamic acid tert-butyl ester

Product 1

HCID 672446015-(4-Aminomethyl-phenyl)-6-methoxy-nicotinonitrile

Sources & evidence

ORD record: ord-ebbf9066e75e44df86cdb0b7ac814712
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (8/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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