4-(5-Bromo-2-propoxy-phenyl)-6-chloro-pyrimidin-2-ylamine → 4-(5-Bromo-2-isopropoxy-phenyl)-6-chloro-pyrimidin-2-ylamine

HRID 28630

Reaction equation

HRID 28630 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:16][CH2:17][CH2:18]C)=[C:6]([C:8]2[CH:13]=[C:12]([Cl:14])[N:11]=[C:10]([NH2:15])[N:9]=2)[CH:7]=1.N[C:21]1N=C(C2C=C(Br)C=CC=2O)C=C(Cl)N=1>CC(O)C>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:16][CH:17]([CH3:18])[CH3:21])=[C:6]([C:8]2[CH:13]=[C:12]([Cl:14])[N:11]=[C:10]([NH2:15])[N:9]=2)[CH:7]=1

Participants

4

Reactant 2

HCID 860043744-(5-Bromo-2-propoxy-phenyl)-6-chloro-pyrimidin-2-ylamineHCID 1360800122-(2-Amino-6-chloro-pyrimidin-4-yl)-4-bromo-phenol

Product 1

HCID 860043764-(5-Bromo-2-isopropoxy-phenyl)-6-chloro-pyrimidin-2-ylamineYield 68%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Following the method described in Example 135 for the synthesis of 4-(5-bromo-2-propoxy-phenyl)-6-chloro-pyrimidin-2-ylamine, 2-(2-amino-6-chloro-pyrimidin-4-yl)-4-bromo-phenol and 2-propanol provided 4-(5-bromo-2-isopropoxy-phenyl)-6-chloro-pyrimidin-2-ylamine (68% yield).

Sources & evidence

ORD record
ord-a8a274a39dbc40e5a3ced3e7e15c9ed8
Source dataset
uspto-grants-2008_09
Patent number
US07419984B2

Linked notes

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