4-(5-Bromo-2-propoxy-phenyl)-6-chloro-pyrimidin-2-ylamine → 4-[5-Bromo-2-(2-methoxy-ethoxy)-phenyl)-6-chloro-pyrimidin-2-ylamine

HRID 28635

Reaction equation

HRID 28635 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:16][CH2:17][CH2:18]C)=[C:6]([C:8]2[CH:13]=[C:12]([Cl:14])[N:11]=[C:10]([NH2:15])[N:9]=2)[CH:7]=1.NC1N=C(C2C=C(Br)C=C[C:28]=2[OH:34])C=C(Cl)N=1>COCCO>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:16][CH2:17][CH2:18][O:34][CH3:28])=[C:6]([C:8]2[CH:13]=[C:12]([Cl:14])[N:11]=[C:10]([NH2:15])[N:9]=2)[CH:7]=1

Participants

4

Reactant 2

HCID 860043744-(5-Bromo-2-propoxy-phenyl)-6-chloro-pyrimidin-2-ylamineHCID 1360800122-(2-Amino-6-chloro-pyrimidin-4-yl)-4-bromo-phenol

Product 1

HCID 860043804-[5-Bromo-2-(2-methoxy-ethoxy)-phenyl)-6-chloro-pyrimidin-2-ylamineYield 42%

Reagents, catalysts & solvents 1

HCID 80192-MethoxyethanolSolvent

Procedure

Following the method described in Example 135 for the synthesis of 4-(5-bromo-2-propoxy-phenyl)-6-chloro-pyrimidin-2-ylamine, 2-(2-amino-6-chloro-pyrimidin-4-yl)-4-bromo-phenol and 2-methoxy-ethanol provided 4-[5-bromo-2-(2-methoxy-ethoxy)-phenyl)-6-chloro-pyrimidin-2-ylamine (42% yield).

Sources & evidence

ORD record
ord-999ac6a17c854f6d814498b7c611ec8a
Source dataset
uspto-grants-2008_09
Patent number
US07419984B2

Linked notes

Loading…