Benzyl Bromide → 4-(2-Benzyloxy-5-chloro-phenyl)-6-chloro-pyrimidin-2-ylamine

HRID 28644

Reaction equation

[NH2:1][C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[C:12]([Cl:14])[CH:11]=[CH:10][C:9]=2[OH:15])[CH:5]=[C:4]([Cl:16])[N:3]=1.Br[CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[CH2:18]([O:15][C:9]1[CH:10]=[CH:11][C:12]([Cl:14])=[CH:13][C:8]=1[C:6]1[CH:5]=[C:4]([Cl:16])[N:3]=[C:2]([NH2:1])[N:7]=1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

Reactant 2

HCID 7498Benzyl Bromide

HCID 1363418892-(2-Amino-6-chloro-pyrimidin-4-yl)-4-chloro-phenol

Product 1

HCID 860043874-(2-Benzyloxy-5-chloro-phenyl)-6-chloro-pyrimidin-2-ylamineYield 56%

Procedure

Following the method described in Example 72, 2-(2-amino-6-chloro-pyrimidin-4-yl)-4-chloro-phenol and bromomethyl-benzene provided 4-(2-benzyloxy-5-chloro-phenyl)-6-chloro-pyrimidin-2-ylamine (56% yield).

Sources & evidence

ORD record: ord-55df34c9fbad45928bdd8945f193897f
Source dataset: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07419984B2

Linked notes

Loading…