Water → tert-butyl 3-[({4-[(1-{2-[(3-fluorophenyl)amino]-2-oxoethyl}-1H-pyrazol-4-yl)amino]quinazolin-7-yl}oxy)methyl]pyrrolidine-1-carboxylate
Reaction equation
[C:29](=[O:30])([O-:31])[O-:32].[C:54]([N:55]([CH3:56])[CH3:57])(=[O:58])[CH3:59].[CH3:35][S:36]([O:37][CH2:40][CH:41]1[CH2:42][N:43]([C:46](=[O:47])[O:48][C:49]([CH3:50])([CH3:51])[CH3:52])[CH2:44][CH2:45]1)(=[O:38])=[O:39].[Cs+:33].[Cs+:34].[F:1][c:2]1[cH:3][c:4]([NH:8][C:9]([CH2:10][n:11]2[n:12][cH:13][c:14]([NH:16][c:17]3[n:18][cH:19][n:20][c:21]4[cH:22][c:23]([OH:27])[cH:24][cH:25][c:26]34)[cH:15]2)=[O:28])[cH:5][cH:6][cH:7]1.[OH2:53]>>[F:1][c:2]1[cH:3][c:4]([NH:8][C:9]([CH2:10][n:11]2[n:12][cH:13][c:14]([NH:16][c:17]3[n:18][cH:19][n:20][c:21]4[cH:22][c:23]([O:27][CH2:40][CH:41]5[CH2:42][N:43]([C:46](=[O:47])[O:48][C:49]([CH3:50])([CH3:51])[CH3:52])[CH2:44][CH2:45]5)[cH:24][cH:25][c:26]34)[cH:15]2)=[O:28])[cH:5][cH:6][cH:7]1
